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Studies have suggested that increased susceptibility to KBD in selenium-deficient populations might result from a reduced antioxidant protection associated with polymorphisms in GPX genes (60, 61), but polymorphisms in other genes have also been implicated (62)

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As per the Center for Disease Control (CDC), about 10 percent of the U.S

Mol Gen Genet 237:351358 Acknowledgements We are grateful to Miss Mari Aoyama and Miss Haruka Matsuyama, Gifu University, for her skilful assistance

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