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Conclusion: Our study findings provide a comprehensive metabolomic knowledge base and other soluble biomarkers for a better understanding of the pathophysiology of LC and suggests sarcosine and serine supplementations might have potential therapeutic implications in LC patients

Side effects are rare but may include nausea, mild headaches, or allergic reactions in some individuals

In one randomized controlled trial, significant improvements compared with placebo were observed on the MADRS and Bipolar Depression Rating Scale (BDRS) and on secondary outcome measures of clinical status, quality of life, and functioning [142]

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Furthermore, both healthcare providers and patients demonstrate low levels of engagement with and implementation of these evidence-based protocols (Jnsson et al., 2019