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Moreover, Emir et al

Initially, it was hypothesized that this heme, along with the Fe-S clusters, would be part of the redox chain that mediates electron transfer from succinate to CoQ

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Consequently, ferroptosis inhibitors and antioxidants have become focal points in clinical intervention research (9)

BRISC-SHMT2 has been shown to disassemble the K63-ubiquitin chain on IFNAR1, thereby limiting receptor endocytosis and lysosomal degradation and regulating protein turnover of IFNAR1, independently of the catalytic activity of SHMT2