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Intestinal metaplasia in the esophagus (Barretts esophagus) could occur because of chronic acid reflux from your stomach into your esophagus

doi:10.1001/jama.2024.9217

Experimental evidence has shown that introducing CGRP into the periaqueductal gray area can enhance TCC nociceptive transmission [33], while CGRP antagonism has the opposite effect, inhibiting this transmission [32]

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