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However, alcohol interacts with the other B vitamins that B12 needs to do its jobs

Behav Pharmacol 2017;28:112-23

10.1038/s41467-023-43801-2

In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)