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doi: 10.1038/s41598-018-36162-0 57 GhoshS

GHK is a naturally-occurring tripeptide (sequence: Gly-His-Lys) present in human plasma at low physiological concentrations

In addition, as an epigenetic modification, DNA methylation can be involved in disease progression and serve as a marker of environmental exposures, such as tobacco smoking, lipid peroxidation, and inflammation ( GSTA4 promoter, which contains antioxidant response elements, may act as an adaptive mechanism through which they are transcriptionally activated during exposure to lipid peroxidation of the vascular wall in IA patients ( GSTA4 methylation may serve as a biomarker of vascular impairment in patients with IA

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In summary, pH-sensitive cleavable linkers are crucial for targeted cancer therapy, allowing for selective drug release in response to the acidic microenvironment of tumors or within cellular compartments