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Importantly, EC-induced oral dysbiosis disrupts microbial homeostasis, fostering pathogenic proliferation and metabolic alterations that contribute to a spectrum of oral pathologies, including periodontitis and oral carcinogenesis

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Frank Leslies Illustrated Newspaper carried a running advertisement for Oco or Dental Snuff, a tobac en poudre dentifrice endorsed by Paris as the most useful and elegant toilette article in the world, divested of its objectionable qualities, and retaining its powers as a disinfectant and detergent. It came in two formsSilver-Banded Oco, Designed expressly for the Northern marketretains all of its powers as a dentifricethough greatly reduced in its stimulating properties and Golden-Banded Oco, retains all its natural strength and pungency, presumably for the Southern market.[9] The type of wood used for brushes was a matter of personal choice

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