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The enzyme nudix hydrolase 15 (NUDT15) is directly involved in the metabolism of thiopurines by catalyzing the conversion of active metabolites to less toxic metabolites, thus preventing the incorporation of toxic metabolites into DNA

PSC would be a consideration if the patient had a history of ulcerative colitis

For professionals working with clients interested in peptide research, sequential approaches often provide better risk-benefit profiles when exploring novel combinations

Early-phase studies report reductions in food and substance cravings, though more research is needed to validate these outcomes in broader populations

Pernicious anemia, Hashimotos thyroiditis and Sjgrens in a woman with SLE and autoimmune hemolytic anemia