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Almost half of IBS patients taking melatonin showed improved quality of life, which was significantly higher than those taking a placebo.[ref] Related article: IBS Genes Melatonin Genotype Report: Not a member

The Hippo pathway effector TAZ also promotes ferroptosis by activating NOX4 and NOX2 in renal cell carcinoma and ovarian cancer cells, respectively (Yang et al., 2019