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Multifactorial Etiology of Adolescent Nicotine Addiction Parental and Peer Influence Epidemiological and clinical data have shown that exposure to tobacco or nicotine can lead to subsequent abuse of nicotine and other recreational drugs in adolescents, and this phenomenon is described as the gateway hypothesis ( Nicotine dependence, depression, and parental socioeconomic factors, contribute significantly to poor health in early adulthood and adolescence ( Parental smoking and nicotine dependence directly increases child onset of smoking, daily smoking and nicotine addiction ( Genetic Influence on Nicotine Dependence Genetic Predisposition confers liability to nicotine dependence and variation in individual genes have been associated with nicotine dependence

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