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Before commencing thionamides, all patients should have baseline full blood examination and liver function tests performed

doi: 10.1172/jci110209

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Several factors can lead to the uncontrolled production of ROS, including damage to the mitochondrial complex I and III, which are the major sources of ROS, reduced ATP production, or malfunctioning of enzymes such as superoxide dismutase (SOD) that convert ROS into non-toxic molecules (Elfawy and Das, 2019)

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