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Biomarker analyses from a placebo-controlled phase II study evaluating erlotinib +/ onartuzumab in advanced non-small cell lung cancer: MET expression levels are predictive of patient benefit

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Their data indicated the importance of targeting the tumor microenvironment by blocking epigenetic mechanisms, which control critical events for colonization such as HGF/c-Met axis as a potential therapy of bone metastasis [40]

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