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SAM is the primary methyl donor, which is a fancy way of saying its a delivery truck that drops off little tags (methyl groups) throughout the cell

J Cell Biol 138:13791394 Chen C, Krausz KW, Idle JR, Gonzalez FJ (2008) Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice

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