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Preclinical Observations Findings observed in murine studies include: Endurance capacity: Increased treadmill running time and distance Mitochondrial function: Enhanced respiration and ATP production in muscle Cardiac metabolism: Improved fatty acid utilization in models of heart failure Renal function: Reduced mitochondrial dysfunction and inflammation in aging kidney models Metabolic profile: Improved glucose handling in metabolic syndrome models These results are limited to animal models using intraperitoneal injection
Poor nutrition can cancel out whatever benefits the injections provide
The injections are prescribed by a doctor and given intramuscularly, or into muscle
Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system
Red flags requiring urgent assessment include rapidly progressive neurological symptoms, new onset ataxia or gait disturbance, visual changes, severe weakness, or confusion
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