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It would be ideal to create reconstituted systems to examine the sphingolipid contribution to the fusion mechanism, such as those done with SNAREs and proteoliposomes (Zick et al., 2014)

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Acknowledgements The authors are supported by US NIH grants R01-DK55758, R01-DK099110, R01-DK127274, R01-DK143576 and R01-DK131537 and P01-AG051459 to P.E.S

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