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The applicant stated that VEST is the only technology that has been proven to prevent common vein graft failures as a result of graft kinking and vein graft disease (intimal hyperplasia)

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This initial period of acclimation can sometimes manifest as mild, transient side effects

Alatzoglou KS, Turton JP, Kelberman D, Clayton PE, Mehta A, Buchanan C, Aylwin S, Crowne EC, Christesen HT, Hertel NT, Trainer PJ, Savage MO, Raza J, Banerjee K, Sinha SK, Ten S, Mushtaq T, Brauner R, Cheetham TD, Hindmarsh PC, Mullis PE, Dattani MT

This is often described as the Gene Expression Paradox, a phenomenon where a short-lived peptide initiates a permanent healing cascade