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Methods A daily dose of Sildenafil (1.48 mg/kg), Tadalafil (0.285 mg/kg) and Vardenafil (0.285 mg/kg) were administered orally to male rabbits for 12 week

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Mechanistically, TRF inhibited the expression of epidermal E-cadherin, resulting in the increased nuclear translocation of -catenin and its interaction with Tcf3

Given its ample range of functions in the nervous system, it is not surprising to find significant alterations in glutathione levels and/or glutathione-related enzymes during brain aging and in several neurological conditions including Parkinson's disease (PD), Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), schizophrenia, and chronic fatigue syndrome (CFS)