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Research on glutathione peroxidase began in the 1950s with the discovery of GPx1 as an enzyme protecting red blood cells from oxidative breakdown

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They simultaneously enhance regulatory T-cell (Treg) activity and facilitate macrophage reprogramming to an anti-inflammatory phenotype (IL-10), thereby reestablishing Th17/Treg ratios that are altered in autoimmune POF (He et al

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