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This is mechanistically interesting but does not establish clinical outcomes

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The combined therapy of ADA with MTX was compared against the mono therapies of ADA and MTX, based on DAS28(CRP) remission rates, ACR20/50/70 response rates [54], and against placebo too in randomized control trial settings (RCTs) [55] and disclosed significant efficacy and improvement in the above-stated parameters [56]

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