While no single method can fully capture the complexity of antioxidant mechanisms, each-whether in vitro, ex vivo, or in vivo-offers distinct advantages in vitro provides mechanistic insights, ex vivo reflects near-physiological conditions, and in vivo yields real-world biological responses (Matute et al., 2021
Lastly, this and previous studies appear to pinpoint to a shared, common paradigm in that various nuclear hormone receptors transcriptionally regulate the expression of specific lipid metabolic enzymes, which in turn alter the cells sensitivity to ferroptosis induction
Time remains the main factor in elimination
doi: 10.3390/molecules28135246
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