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These effects are believed to be related to the broader systemic benefits of optimized GH circulation on brain function and hormonal balance

The initial insult can be followed by a regenerative hyperplastic response

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Insulin enhances glucose uptake into hepatocytes, activates glycogen and FFA synthesis (in adipocytes), and accelerates cellular glucose metabolism, whereas THs increase hepatic glucose output, increase GLUT2 expression in hepatocyte membranes, inhibit glycogenesis, and activate gluconeogenesis [25]