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Other MTHFR Symptoms by Body System Neurological Symptoms: Brain Fog, Anxiety, and Irritability MTHFR gene mutations can significantly impact your nervous system because methylation is essential for producing neurotransmitters like serotonin, dopamine, and norepinephrine the chemical messengers that regulate mood, focus, and mental clarity

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Addressing low B12 levels can also help reduce symptoms like brain fog and difficulty focusing