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When Ive looked at literature on methylene blue, Ive only found one case report of toxicity in humans

Holding the dose longer or adjusting to a customized intermediate dose may improve tolerability

Beyond Fat Loss: Cartilage and Joint Health Data A 2015 rabbit osteoarthritis model found that intra-articular injection of AOD-9604 at 0.25 mg weekly over 47 weeks enhanced cartilage regeneration, with greater effect when combined with hyaluronic acid

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Most B12 is Cyanocobalamin, a synthetic form your body has to convert