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Espe M, Lai F, Gomes AS, De Santis C, Hartviksen MB, Holen E, Rnnestad I

Psychiatry 7 , e1138 (2017)

It also exhibits analgesic and anti-inflammatory properties, accelerating the healing of sprains, tears, and tissue damage by increasing blood flow to injured areas

In later stages, heightened central nervous system inflammation fuels disease progression and exacerbates BBB dysfunction, with heightened levels of enzymes like MMP-9 exacerbating this breakdown

C-terminal FLAG-tagged A39 construct with all four cysteines mutated to alanine, A39 4CA -FLAG, can fully restore mitochondrial GSH depletion in the A39 CRISPR KO cells similar to the wild type A39-FLAG (Fig