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(PubMed) Liu B, Mao Q, Wang X, et al

Additional animal studies have confirmed that ameliorating microbial dysbiosis delays the AKI-to-CKD transition by elevating SCFA levels, improving intestinal barrier function, and modulating inflammatory responses [171]

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Nrf2 directly regulates the expression of SLC7A11, glutamate-cysteine ligase catalytic subunit (GCLC), glutamate-cysteine ligase modifier subunit (GCLM), and glutathione synthase (GSS), which catalyze GSH synthesis, thereby enhancing GPX4 activity and suppressing ferroptosis (Zhang, 2025)