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doi: 10.3390/ijms20051040 7 DengC.WuY.LvX.LiJ.LiuY.DuG.et al

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Research indicates that 20%30% of diabetic patients may eventually develop DCM, and the risk of heart failure among these patients exceeds 70% (6, 7)

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The D-amino acid substitution preserves the spatial orientation of amino acid side chains needed for competitive binding to the FOXO4-p53 interaction surface, maintaining biological activity despite the non-natural backbone (PMID: 28340339)

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