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66,67 Therefore, contribution to cyclosporine nephro- and hepatotoxicity has been postulated to be caused by its generation of free radicals and depletion of GSH

Studies such as those by Yin et al

Promo until 28 February 2026 DOH-FDA-CFRR Permit No

Extensive experimental and computational studies have shown that the binding of GSH to GSTs decreases the p K a of the GSH thiol group from around 9 to about 6 in the active site through hydrogen bonding and salt bridges and through the positive electrostatic potential of the G-site 41,42

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