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Trained immunity exerts long-lasting effects on cell function through epigenetic regulation and metabolic reprogramming ( Table 1 ) and shows bidirectional roles in immune regulation: disease-induced trained immunity can, in turn, exacerbate pathology, creating a self-reinforcing vicious cycle

[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Terunuma M., Vargas K.J., Wilkins M.E., Ramrez O.A., Jaureguiberry-Bravo M., Pangalos M.N., Smart T.G., Moss S.J., Couve A

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