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In the most apical region of the epithelium there is an intercellular gap (around 90 ) named zonula occludens or tight junctions, followed by the zonula adherens (gap of 200 ), followed by the macula adherens or desmosomes (gap of ~240 ) (7)

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For example, selenium-containing nanomicelles (PEGPUSePEG/Pt) respond to elevated intracellular GSH by reducing platinum ions from the micelle core, thereby releasing encapsulated doxorubicin (DOX)

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