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But sometimes, these contractions can get stronger and last longer, which can make the pain feel worse

To make matters worse, overproduction of tobacco in the 1660s and 1670s drove the price of the crop to an all-time low, just as the second and third Anglo-Dutch wars disrupted trade and colonists were obliged to raise taxes to pay for troops and fortifications

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Symptoms of an overdose include nausea, abnormal pain, vomiting, diarrhea, cold sweat, dizziness, disturbed hearing and vision, mental confusion, rapid heartbeat, dificulty breathing and marked weakness