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Activation of this pathway has been associated with the promotion of cell survival, inhibition of apoptosis, and a reduction in neuroinflammation [227]

Most signals map to genes involved in pancreatic -cell development and function, insulin signaling, and glucoselipid homeostasis, supporting the view that T2DM reflects not only peripheral IR but also intrinsic liabilities in insulin production and secretion

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This highlights the need to better understand the relationship between oral antioxidant supplements and oxidative stress levels to better identify the patients who would benefit from supplementation, as well as the optimal combinations and dosage of each supplement