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10.2337/cd16-0018 279 SturmG

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Vitamin C mechanisms involve serving as enzymatic cofactor for collagen hydroxylation and providing direct antioxidant protection, creating effects requiring ongoing application for maintaining antioxidant benefits but potentially supporting durable collagen improvements if used sufficiently long

2 Department of Biological Science, Purdue University, West Lafayette, IN, USA *These authors contributed equally to this work Abstract: Glutathione S-transferase (GST) is a Phase II metabolic enzyme that is an important facilitator of cellular detoxification