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Cerebral blood flow in human female preterm neonates is 18% lower than males ( The elimination of 7,8-DHF has been found to be primarily through glucuronidation, sulfation, and methylation ( Ex vivo metabolism might have contributed to the quantitation of these metabolites

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However, unlike pro-fibrotic agents, GHK-Cu also upregulates the activity of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), facilitating the breakdown of scarred or disorganized collagen