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J Biol Chem 274(17):1145511458

FOXO4-DRI is a large peptide (~5382 Da, 48 amino acids) with a critical structural modification: the D-Retro-Inverso (DRI) design uses D-amino acids in reversed sequence to confer protease resistance while maintaining the 3D spatial arrangement needed for target binding

The physiological importance of copper import is further underscored by the essential role of the standard importer SLC31A1, as evidenced by reduced cardiac copper levels in SLC31A1-deficient mice [50, 58]

Reconstitution Steps Reconstitution of a blend is identical to a single peptide the only difference is that one volume carries two peptides at a fixed ratio