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The metabolic effect of inadequate thyroid hormone is partly to blame

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While more inclusive diagnostic criteria, improved screening, and greater cultural acceptance have all contributed, the staggering numbers over the last 40 years point to a genuine surge in prevalence

However, in low-body-weight infants, short-duration, intermittent HD is a safe and effective way to ensure rapid reversal of hyperammonaemia and enable the patient to recover between dialysis sessions, which prevents HD-related prolonged hypotension, membrane clotting and prolonged heparinization 46

For example, mutations in the p53 tumor suppressor gene, often caused by oxidative stress, are frequently observed in various cancers [99]