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MIA reprograms microglia in a phenomenon known as trained immunity (otherwise known as innate immune memory) to enhance immune responses or suppress immune pathways to confer immune tolerance [51] via epigenetic modulations involving histone modifications, DNA methylation, chromatin remodeling, and miRNAs [52]

(PubMed) Hadzik B, Grass H, Mayatepek E, Daldrup T, Hoehn T

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Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid