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The satiety produced by amylin analogues tends to reduce caloric intake without the extreme food aversion that sometimes occurs with high-dose GLP-1 agonists, which can lead to inadequate protein intake and subsequent muscle loss

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It mimics the incretin hormone GLP-1 to enhance glucose-dependent insulin secretion, suppress glucagon, slow gastric emptying, and reduce appetite through central pathways

Individual health history, current medications, and aesthetic goals all inform the best approach

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