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Mitochondria are central to the regulation of apoptosis, where pro-apoptotic signals trigger OMM permeabilization, releasing pro-apoptotic factors like cytochrome c and activating caspases

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In smoking mouse models, vitamin D deficiency initially does not affect muscle mass but, over time, leads to elevated lipid peroxidation, which, in combination with smoking, accelerates muscle loss and atrophy (62)

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Avoid vials containing loose, yellowed, or completely melted powder, as this indicates moisture intrusion or heat damage