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Conversely, patients with SIBO also had a higher intestinal permeability

doi: 10.1101/2025.07.07.25329844 56 ChanYLLiaoJCLiTLWuCJChiuYH

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If the presence of an initial stressor is prolonged, the HPA axis will become chronically activated and trigger the overproduction of cortisol which, over time, will result in a reduction in cortisol levels (427)