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57 LiuY.YuX

While this unidirectional behavior effectively destroys cell metabolism for tumor suppression, it poses challenges because of the absence of coupling between the intracellular nanostructures and endogenous feedback mechanisms, thereby hindering their translation to scenarios requiring sustained cellular viability and precise, nondestructive function modulation, including probiotic interventions 46 , programmable cell-based therapeutics 47 and engineered living materials 48

10.1038/s41418-018-0212-6 48 FreiB.KimM

These results suggest that similar metabolic alterations occur in murine and human kidneys with TLS and that urinary GSH could be a noninvasive diagnostic biomarker to detect TLS in the kidney

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