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Graham IM, Daly LE, Refsum HM, Robinson K, Brattstrm LE, Ueland PM, Palma-Reis RJ, Boers GH, Sheahan RG, Israelsson BJJ (1997) Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project

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Thus, the review will be carefully interpreted regarding differences in experimental design, internal validity, quality of evidence, and risk of bias to allow the results of studies based on animal models to support future clinical trials [31]

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