The current anti-lipid medicines dont affect its levels much either the best drug we have now is the PCSK9 inhibitor, Evolocumab, which only reduces the levels of Lp(a) by about 20%
Unfortunately once chronic inflammation becomes entrenched and mitochondria oxidatively stressed (less CYP27B1) exogenous 1,25(OH) 2 D3 is needed (Warren et al., 2021)
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