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Functional instability involves neuromuscular deficits including impaired proprioception, delayed muscle reaction times, and poor motor control that persist even when mechanical structures appear intact

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doi:10.1007/s00439-011-0989-6

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Consistent with this, AI-based structural prediction 74 indicated a direct interaction between NHR-49 and XPO-1 that required its small GTPase cofactor RAN-1 (ipTM = 0.66 versus 0.54 without RAN-1) (Fig