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On the other hand GPx3 is negatively correlated with MAPK oncogenic signaling pathway (94), which suggests a potential antitumor effect in thyroid cancer, while a decrease in GPx3 levels predisposes to an increase in the size of primary tumors and the number of metastatic lymph nodes (95, 96)
While astrocytes were historically considered to appear morphological changes in response to injury, trauma, aging, and neurodegeneration (Stephenson et al., 1999
doi: 10.1136/rmdopen-2023-004025 136
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