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Activated macrophages (M1 type macrophages) invade the synovium, and the imbalanced ratio of M1 type and anti-inflammatory macrophages (M2 type) in synovial tissues as well as the differentiation of macrophage precursor cells into osteoclasts are important characteristics of RA (203)

Hypoxia-inducible factor-1a regulates the interleukin-6 production by B cells in rheumatoid arthritis

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Adang AE, Brussee J, van der Gen A, Mulder GJ