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More precisely, among them, the cyclin-dependent kinase inhibitor p21 Cip1/WAF1 , induced by p53 in response to OS and involved in the regulation of cell cycle arrest, replication, cellular proliferation, and apoptosis, competes with KEAP1 for the binding to NRF2 through the DLG motif, thus preventing NRF2 ubiquitination, and increasing its stabilization [184, 185]

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doi: 10.5415/apallergy.2022.12.e23 206

Systematic review of Crizanlizumab: a new parenteral option to reduce vaso-occlusive pain crises in patients with sickle cell disease

Exp Cell Res 347(2):251260 Park SJ, Wu CH, Gordon JD, Zhong X, Emami A, Safa AR (2004) Taxol Induces Caspase-10-dependent Apoptosis