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Vukojevic et al., 2018) and those with bile duct induced liver cirrhosis and portal hypertension (Sever et al., 2019)

This chronic inflammation explains why traditional pain medications provide only temporary relief

One individual per group was euthanized before addressing the next animal in each group to render differences arising from the time of day at euthanization (e.g., cecal mass changes resulting from differences in time post-food consumption) comparable across all groups

The peptide is remarkably stable in lyophilized form but becomes sensitive once reconstituted

Because the treatment bypasses the digestive system, it reduces the likelihood of stomach discomfort or other gastrointestinal side effects