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In some embodiments, the otic formulation or composition comprises between about 0.01% to about 80% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

Sulfasalazine, with its antiarthritic sulfapyridine moiety, may provide some relief of arthritic symptoms

doi: 10.31436/jop.v3i1.156 181 CasulaLCraparoEFLaiEScialabbaCValentiDSchlichMet al

Additionally, the NADPH/FSP1/CoQ10 pathway, through the action of FSP1, reduces CoQ10 with NADPH, further inhibiting lipid peroxidation and ferroptosis (Frei et al., 1990)

It modulates gene expression broadly downregulating NF-B inflammatory programs while upregulating antioxidant and repair pathways