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However, a notable side effect was observed: MT-II-treated normal C57BL/6J mice exhibited significant weight loss, with their average weight decreasing from a baseline of 30.9 1.4 grams to 26.5 1.7 grams after the 14-day treatment course, a change not seen in vehicle-treated controls

[11] Because these vitamins are not long-term cumulative drugs (they dont maintain stable plasma levels like a blood pressure medication would), missing one dose is usually not critical