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Sleep deprivation exacerbates microglial reactivity and A deposition in a TREM2-dependent manner in mice

After stopping a CYP3A4 inducer, as the effects of the inducer decline, the hydrocodone plasma concentration will increase [see CLINICAL PHARMACOLOGY], which could increase or prolong both the therapeutic effects and adverse reactions, and may cause serious respiratory depression

The graduated escalation schedule minimizes these risks

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PAMPs, pathogen-associated molecular patterns